Design of experiments for cell culture, fermentation and media optimization. Pick the right design, see how many runs you need, and read your results in plain language.
Watch the same CHO titre landscape explored two ways. One-factor-at-a-time crawls along the edges and stops short. A designed experiment maps the whole space and lands on the peak.
Around a third fewer runs, and it actually finds the optimum the edge-crawling search walked straight past.
Every designed experiment climbs the same six stages, from a question to a model you can act on. The tool guides you through each one — scroll to follow the path.
What are you trying to improve?
Temperature, pH, feed, media…
Titre, growth, byproducts.
The guided picker recommends it.
Run the randomised sheet.
Plain-language answer + report.
Every DOE design leans toward a purpose. Screening finds which factors matter, optimization locates the best setpoint, and interaction designs capture how factors work together. The picker maps your goal to the right one.
Move the slider and hover the surface to read any point. This is the real plotting engine on a demo CHO dataset — the same response surface you get in the tool.
The flat contour above is a top-down view of this surface. Drag it to tilt. The star marks the predicted optimum — the peak your runs are hunting for.
Demo data, for illustration. With the real tool your own data never leaves your browser.
The tool builds the design, ranks what matters, fits the model, and tells you where to go next in one sentence. Example: a CHO fed-batch study with pH, Temperature, DO, Feed and Osmolality.
The free tool is a full DOE engine. Pro adds the bioprocess intelligence and the audit trail that turn a good experiment into a submission-ready one.
A Gaussian-process model will suggest the next run most likely to improve your result, so the best-so-far titre climbs with every cycle. Not included in DOE Pro today — in development, and free to existing subscribers when it ships.
Everything below is in DOE Pro today. Start from a validated bioprocess preset, right-size the study, and export a report your quality team will accept.
Around 3-4× cheaper, with no quote, no sales call, and no seat you lose when you change jobs. Public list prices, mid-2026.
On the points researchers actually complain about. Prices are public figures as of mid-2026; several incumbents are quote-only.
| Tool | Price | Runs in browser | Easy for non-statisticians | Bioprocess presets | One-click GMP report | No licence lock-in |
|---|---|---|---|---|---|---|
| This tool (DOE Pro) | Free / $39.99 mo | Yes | Guided + plain language | Yes | Yes | Yes |
| JMP | ~$1,390 / yr | Desktop | Stats background | No | No | Annual seat |
| Minitab | ~$1,851 / yr | Mostly desktop | Stats background | No | No | Named seat |
| Design-Expert | Quote-only | Desktop (Win) | DOE-focused | Generic | No | Perpetual or sub |
| MODDE (Sartorius) | Quote-only | Desktop + cloud | Stats background | Yes | Yes | Enterprise |
The free tool stays free. Pro is a small fraction of the desktop incumbents, with no quote and no sales call.
Yours to keep. No subscription.
A plain-language DOE playbook plus print-and-fill worksheets for the bench. 11 pages, A4.
Free forever. No card.
The full classical DOE engine, guided design picker and run-count comparison.
Then $39.99/mo. Cancel anytime.
The bioprocess-aware DOE tool in your browser.
Cancel anytime
Half price for 6 months of a 12-month plan, so you save $107.50 off your first year. Then $429.99/yr. Cancel anytime.
Cheaper than monthly every year
Cancel anytime
Built by bioprocess engineers. Vendor-neutral. Cancel anytime.
Payments handled by Lemon Squeezy (merchant of record). Tax added at checkout where applicable. Introductory pricing applies for the stated period, then renews at the standard price.
Refunds & cancellation · Terms · Privacy · support@bioprocesstools.com
Yes. This is a free, browser-based design of experiments tool. It generates factorial, fractional factorial, Plackett-Burman, central composite, Box-Behnken and definitive screening designs and analyzes the results, with no install and no licence. A Pro tier adds bioprocess presets, run-efficient designs and a one-click GMP/QbD report.
Yes. The tool runs entirely in your browser on any operating system, including Mac and Linux, with nothing to install and no IT ticket. You can share a design with a colleague by sending a link.
No. A guided picker asks a few plain questions and recommends the right design, and every result is explained in plain language, so you do not need a statistics degree or a statistician to run a proper experiment.
Tell the tool how many factors you have, whether you are screening or optimizing, and whether any factors are hard to change. It recommends the right design and explains why.
The run-count comparison shows every candidate design side by side with the number of runs and what each can estimate, plus a power check, so you can right-size the study before committing to costly bioreactor runs.
Yes. Pro includes 11 bioprocess presets covering CHO (media, fed-batch and amino-acid feed), E. coli, Pichia, Sf9 baculovirus, and mAb downstream steps (Protein A, CEX, AEX, HIC and formulation), byproduct-ceiling optimization (for example capping lactate or ammonium while maximizing titre), and handling for setpoints that cannot be re-randomized between runs.
Yes. The Pro tier exports a one-click validation report with your design, analysis, plots, company logo, an audit trail and ICH Q8/Q14 design-space framing, ready to drop into a submission.